• br Results br Discussion The inflammasome consists of the

  2022-07-14

  

  Results Discussion The inflammasome consists of the sensor molecule nucleotide oligomerization domain (NOD)-like receptors (NLRs), the adaptor protein ASC, and the mk-801 molecule CASP1 (Guo et al., 2015). Among the different types of inflammasome, the NLRP3 inflammasome requires a priming st

• In this study it was demonstrated that

  2022-07-14

  

  In this study it was demonstrated that also in mice chronically exposed to CS, lung inflammation persists after SC and is associated with a progressive alveolar loss and remodeling of respiratory tract, characterized by the onset of bronchial and bronchiolar GCM and peribronchiolar fibrosis. Persist

• Previous research has suggested that differences in spatiote

  2022-07-14

  

  Previous research has suggested that differences in spatiotemporal regulation of intracellular signaling pathways can confer specificity to cellular responses (Marshall, 1995). Conventional approaches based on gain- or loss-of-function genetic manipulations or small-molecule inhibitors, however, lac

• br Acknowledgments br The study was funded by the

  2022-07-14

  

  Acknowledgments The study was funded by the European Commission FP7-project Beta-JUDO (Grant 279153), and Swedish Diabetes Association (Grant DIA 2013-043) and Family Ernfors Foundation (Grant 150430). Free fatty Pyr3 receptors (FFARs) represent a family of G-protein coupled receptors (GPCR

• Genetic contributions to this dysregulation of expression ha

  2022-07-14

  

  Genetic contributions to this dysregulation of expression have been studied, and significant associations have been found. The Fas −670 polymorphism is associated with preterm premature rupture of membranes, preeclampsia, as well as intrauterine growth restriction [7], [16]. The Fas SNP (−670 A>G) i

• It is apparent from the

  2022-07-14

  

  It is apparent from the data in that none of the ligands exhibits significant toxicity as determined by the viability of human embryonic kidney (HEK 293) cells at a concentration of 100 μM. It is also apparent from the data in and that a number of the ligands inhibit the HIV-1 IN enzyme. However,

• This profound cell type specificity of G a GLP complex

  2022-07-14

  

  This profound cell-type specificity of G9a/GLP complex modulation of neuronal plasticity is accentuated by studies employing genetic ablation of G9a in dopamine 1 receptor (Drd1)- and dopamine 2 receptor (Drd2)-expressing medium spiny neurons (MSNs) in the nucleus accumbens (NAc). Conditional G9a kn

• Migration chemotaxis and trafficking of leukocytes including

  2022-07-14

  

  Migration, chemotaxis and trafficking of leukocytes, including eosinophils from the peripheral blood into the site of inflammation requires their adhesion to endothelial SMER 3 (Ley et al., 2007). Despite ongoing research, the histamine effect on eosinophils adhesion to endothelium cells has not be

• Hypoxia HIF and Inflammation Cellular responses to

  2022-07-14

  

  Hypoxia, HIF, and Inflammation Cellular responses to hypoxia are essential for life and are now recognized to be dysregulated in a wide range of disease processes. The key players in these pathways are a family of transcription factors, the hypoxia-inducible factors (HIFs; see Glossary), as well as

• Although historically the two ROCK isoforms have been viewed

  2022-07-13

  

  Although historically, the two ROCK isoforms have been viewed as redundant, recent observations show that the two isoforms of ROCK might have different functions (Newell-Litwa et al., 2015). Knockdown of ROCK1 was found to result in cell rounding and a decrease in cell size while cells with knockdow

• br Concluding remarks br Conflict

  2022-07-13

  

  Concluding remarks Conflict of interest statement References and recommended reading Papers of particular interest, published within the period of review, have been highlighted as: Acknowledgements We thank all the present and former members in our laboratory for their contributions to

• br Results and discussion GSTP is

  2022-07-13

  

  Results and discussion GSTP1 is a Phase II cytoprotective and detoxifying enzyme. Due to its role in the detoxification of numerous endogenous and exogenous chemical agents (with electrophilic functional groups), individuals with Ile105Val mutation in this gene show enhanced risk of atopic disord

• LPCs have been previously described as

  2022-07-13

  

  LPCs have been previously described as potential anti-diabetic factors due to stimulation of secretory activity from the isolated rodent pancreas, L-type cells, ands insulin-producing cell lines, with LPC 18:1 as the main structure of interest (Soga et al., 2005, Sakamoto et al., 2006, Overton et al

• Hair loss in women is

  2022-07-13

  

  Hair loss in women is polygenic and multifactorial with the additional influence of environmental factors. Several studies focused on the importance of several genes related to alopecia (Carey et al., 1993, Hillmer et al., 2008, Randall, 2008). FPHL involves progressive hair follicle miniaturization

• ml7 synthesis br Reaction mechanism The dissimilarity betwee

  2022-07-13

  

  Reaction mechanism The dissimilarity between monofunctional and bifunctional glycosylases is that the monofunctional glycosylases removes the substrate base, leaving an intact AP site while the bifunctional glycosylases have an additional lyase activity. This intrinsic lyase activity is present i

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